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Coenzyme Q 10 Can in Some Circumstances Block Apoptosis, and This Effect Is Mediated through Mitochondria
Author(s) -
KAGAN TERRI,
DAVIS CLAUDETTE,
LIN LIN,
ZAKERI ZAHRA
Publication year - 1999
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1999.tb07920.x
Subject(s) - mitochondrion , apoptosis , coenzyme q10 , mitochondrial dna , microbiology and biotechnology , programmed cell death , inner mitochondrial membrane , coenzyme q – cytochrome c reductase , membrane potential , oxidative damage , dna damage , apoptosis inducing factor , function (biology) , lipid peroxidation , chemistry , biology , enzyme , biochemistry , dna , caspase , cytochrome c , gene
The mitochondrial component coenzyme Q 10 (CoQ 10 b ) Has been used for many years as a Dietary supplement intended to promote good health by trapping free radicals, thus preventing lipid peroxidation and DNA damage. We have tested its use as a generic anti‐apoptotic compound and have found that its ability to protect against apoptosis varies depending on both cell type and mode of cell death induction. We have further established that this protection may be mediated by its effect on mitochondrial function and viability. We provide additional evidence that CoQ 10 's protective effect on mitochondrial membrane potnetial does not always result in altered mitochondrial enzyme activity and neither does it guarantee survival. These observations open the way for further investigations into the mechanisms involved in mitochondrial control of apoptosis.