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Branin Tachykinins and the Regulation of Salt Intake
Author(s) -
FLYNN FRANCIS W.
Publication year - 1999
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1999.tb07889.x
Subject(s) - medicine , endocrinology , chemistry , receptor , taste , ingestion , agonist , neuropeptide , salt (chemistry) , biology , food science
A bstract : The regulation of salt intake is achieved through the coordination of behavioral and pysicological responses. Brain neuropeptides, such as the tachykinins, play an important role in orchestrating both of these responses. Intraventicular injections of NK 3 receptor agonists, such as senktide, are potent in suppressing salt intake. Experiment results show that intraventicular injections of senktide that suppress salt intake have no effect on the ingestion of other tastes, such as sucrose. The means by which senktide suppresses salt intake was investigated in a series of experiments. Taste reactivity and lick rate analyses suggest that the activation of NK 3 receptors reduces salt intake by modulating the ora‐stimulating property of salt taste.