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Discordance between Traditional Pathologic and Energy Metabolic Changes in Very Early Alzheimer's Disease: Pathophysiological Implications
Author(s) -
MINOSHIMA SATOSHI,
CROSS DONNA J.,
FOSTER NORMAN L.,
HENRY THOMAS R.,
KUHL DAVID E.
Publication year - 1999
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1999.tb07852.x
Subject(s) - glutamatergic , neuroscience , entorhinal cortex , cholinergic , disease , alzheimer's disease , pathophysiology , degenerative disease , biology , medicine , hippocampus , glutamate receptor , pathology , central nervous system disease , receptor
These results suggest that neither the loss of entorhinal efferents nor cholinergic deficit explains all the metabolic features seen in very early AD. Given recent immunohistological evidence of massive glutamatergic synaptic alteration in early AD cortex and insights into neuronal and glial mechanisms of glucose metabolism, very early metabolic changes in AD probably reflect a significant impairment of glycolytic activities in the cortico-cortical glutamatergic systems in a preclinical stage of the disease. However, the exact mechanisms of such impairment in these neurons are yet to be determined.