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Expression and Localization of TIMP‐1, TIMP‐2, MMP‐13, MMP‐2, and MMP‐9 in Early and Advanced Experimental Lung Silicosis
Author(s) -
PARDO ANNIE,
PÉREZRAMOS JULIA,
SEGURAVALDEZ LOURDES,
RAMÍREZ REMEDIOS,
SELMAN MOISÉS
Publication year - 1999
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1999.tb07735.x
Subject(s) - humanities , noma , medicine , gerontology , art , power (physics) , physics , quantum mechanics
Chronic exposure to crystalline silica particles results in macrophagelymphocytic granulomatous lung inflammation, which is followed by abnormal and progressive accumulation of extracellular matrix. 1,2 However, the pathogenic mechanisms and the sequence of the pathological events leading to the fibrotic response have not been well defined. In this context, there is evidence suggesting an upregulation of a variety of fibrogenic cytokines such as tumor necrosis factor alpha (TNFα ) and transforming growth factor beta (TGFβ ), with increased synthesis and secretion of lung extracellular matrix components. 3,4 However, studies on matrix degradation are scanty.