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Matrix Metalloproteinase Inhibition: From The Jurassic To The Third Millennium
Author(s) -
WOESSNER J. FREDERICK
Publication year - 1999
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1999.tb07697.x
Subject(s) - matrix metalloproteinase , proteases , matrix metalloproteinase inhibitor , alpha 2 macroglobulin , chelation , metalloproteinase , chemistry , matrix (chemical analysis) , biochemistry , pharmacology , enzyme , biology , macroglobulin , chromatography , organic chemistry
A brief historical introduction to the matrix metalloproteinase (MMP) field, which began in 1962, is followed by an overview of the inhibition of these proteases by natural inhibitors such as α 2 macroglobulin and the TIMPs (tissue inhibitors of metalloproteinases) and by synthetic inhibitors, which are largely chelating agents. The latter include thiol, alkylcarbonyl, phosponamidate and hydroxamate compounds, as well as the tetracyclines. A review of the most recent progress concludes with prognostications as to where the field may be going next.