Premium
INHIBITION OF MATRIX METALLOPROTEINASES THERAPEUTIC APPLICATIONS
Author(s) -
BLAVIER LAURENCE,
HENRIET PATRICK,
IMREN SUZAN,
DECLERCK YVES A.
Publication year - 1999
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1999.tb07677.x
Subject(s) - matrix metalloproteinase , angiogenesis , extracellular matrix , metastasis , matrix metalloproteinase inhibitor , cancer research , function (biology) , homeostasis , microbiology and biotechnology , matrix (chemical analysis) , cell growth , chemistry , cancer , biology , medicine , biochemistry , chromatography
Tissue inhibitors of metalloproteinases (TIMPs) play a key regulatory role in the homeostasis of the extracellular matrix (ECM) by controlling the activity of matrix metalloproteinases (MMPs). Some TIMPs have a second function as well, unrelated to their antiMMP activity, which affects cell proliferation and survival. The role of these inhibitors in cancer has been the subject of extensive investigations that have examined their biological activity in tumor growth, invasion, metastasis and angiogenesis, as well as their potential use in the diagnosis and treatment of human cancer.