Premium
Enhancement of Systemic and Pulmonary Vasoconstriction by β‐Amyloid Peptides and its Suppression by Vasoactive Intestinal Peptide
Author(s) -
SAID S. I.,
RAZA S.,
BERISHA H. I.
Publication year - 1998
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1998.tb11240.x
Subject(s) - veterans affairs , annals , medicine , gerontology , library science , history , classics , computer science
(1) A beta peptides potentiate vasoconstriction, caused by norepinephrine, and possibly other endogenous vasoconstrictors. If this potentiation occurs in the cerebral circulation, close to sites of A beta deposition in AD brains, the enhanced vasoconstriction could result in neuronal ischemia and death. (2) By neutralizing this deleterious effect of A beta, and through other neuroprotective mechanisms, VIP may provide an important defense against neuronal loss in AD.