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Developmental Regulation of Pituitary Adenylate Cyclase Activating Polypeptide (PACAP) and Its Receptor 1 in Rat Brain: Function of PACAP as a Neurotrophic Factor a
Author(s) -
LINDHOLM DAN,
SKOGLÖSA YLVA,
TAKEI NOBUYUKI
Publication year - 1998
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1998.tb11178.x
Subject(s) - adenylate kinase , cyclase , endocrinology , medicine , receptor , chemistry , neurotrophic factors , brain derived neurotrophic factor , function (biology) , pituitary adenylate cyclase activating peptide , biology , neuroscience , microbiology and biotechnology , neuropeptide , vasoactive intestinal peptide
A bstract : To function as a trophic factor PACAP and PACAP‐R must be expressed in the nervous system during early development. We report here on the distribution of PACAP mRNA in the developing nervous system of the rat and compare its expression with that of PACAP‐R. We discuss primary neuron culture experiments that study the neurotrophic activity of PACAP. Experimental results that indicate the presence of PACAP and its receptor in the developing nervous system, together with the observed neuropeptide activity on various populations of neurons, support the view that PACAP exhibits important neurotrophic activities comparable to those of the classical neurotrophic factors.