Premium
Identification of the Autoantigen of Celiac Disease
Author(s) -
SCHUPPAN DETLEF,
DIETERICH WALBURGA,
EHNIS TOBIAS,
BAUER MICHAEL,
DONNER PETER,
VOLTA UMBERTO,
RIECKEN ERNST OTTO
Publication year - 1998
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1998.tb11116.x
Subject(s) - tissue transglutaminase , extracellular matrix , pathogenesis , extracellular , intracellular , disease , immunology , fibrosarcoma , biology , pathology , medicine , microbiology and biotechnology , chemistry , enzyme , biochemistry
Tissue transglutaminase is demonstrated to be the unknown endomysial autoantigen by means of immunoprecipitations from a fibrosarcoma cell culture. A novel hypothesis for the pathogenesis of celiac disease is formulated: The mainly intracellular tissue transglutaminase is released from cells during wound healing where it aids in stabilizing the wound area by cross‐linking a small set of extracellular matrix components.