Premium
Experimental Models to Study Molecular Mechanisms Underlying Intestinal Inflammation
Author(s) -
ELSON C. O.,
CONG Y.,
BRANDWEIN S.,
WEAVER C. T.,
McCABE R. P.,
MÄHLER M.,
SUNDBERG J. P.,
LEITER E. H.
Publication year - 1998
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1998.tb11113.x
Subject(s) - effector , inflammation , antigen , biology , colitis , gene , immunology , disease , inflammatory bowel disease , microbiology and biotechnology , genetics , medicine , pathology
Experimental animal models, particularly the newer mouse models, have convincingly demonstrated that CD + T cells play a central role in chronic intestinal inflammation. Such CD4 + effector T cells are induced by the bacterial flora. In at least one model, it is conventional protein antigens that are stimulating these pathogenic T cells. The antigens driving disease seem to be a selective subset of immunodominant proteins, likely derived from a subset of organisms. Multiple genes contribute to colitis susceptibility and a number of these genes are being localized.