Premium
The Laminins: Role in Intestinal Morphogenesis and Differentiation
Author(s) -
SIMONASSMANN P.,
LEFEBVRE O.,
BELLISSENTWAYDELICH A.,
OLSEN J.,
ORIANROUSSEAU V.,
ARCANGELIS A.
Publication year - 1998
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1998.tb11110.x
Subject(s) - laminin , morphogenesis , microbiology and biotechnology , basement membrane , extracellular matrix , integrin , gene isoform , biology , cellular differentiation , cell , intracellular , cell migration , gene , genetics
Dynamic and reciprocal heterotypic cell interactions are crucial for intestinal morphogenesis and differentiation. This paper emphasizes the role of basement membrane molecules and in particular of laminins as potent mediators in this intercellular cross talk. Changes in the expression or localization of laminin isoforms or of integrins during development and cell migration strengthen the concept that heterogeneity in cell‐matrix interactions could mediate distinct cell responses. A combination of genetic or biochemical approaches associated with in vitro models allows us to study the potential role of each laminin isoform in basement membrane assembly, cell migration, or cell differentiation.