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Inhibitory Effect of Cowdria ruminantium on the Expression of MHC Class I and Class II Molecules on Bovine Endothelial Cells a
Author(s) -
VACHIÉRY N.,
TRAP I.,
TOTTÉ P.,
MARTINEZ D.,
BENSAID A.
Publication year - 1998
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1998.tb11047.x
Subject(s) - mhc class i , mhc class ii , biology , major histocompatibility complex , antigen , endothelial stem cell , microbiology and biotechnology , immunology , in vitro , biochemistry
Bovine endothelial cells constitutively express MHC class I molecules, whereas MHC class II molecules can be induced by interferon gamma (IFNγ) treatment. Endothelial cells may play a role as antigen presenting cells (APC), but their role in the immune response against Cowdria ruminantium is unknown. We have studied the effect of C. ruminantium infection on the expression of MHC class I and class II molecules on the surface of bovine endothelial cells. Bovine brain endothelial cells (BBEC) from the microvasculature and bovine umbilical endothelial cells (BUEC) from the macrovasculature were cultured in vitro , infected with different concentration of Cowdria , and treated or not with IFNγ. We observed that Cowdria induced a reduction of MHC molecules expression on the surface of BUEC and BBEC. This inhibitory effect of Cowdria on MHC molecules could affect the capacity of endothelial cells to act as efficient antigen‐presenting cells.