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Molecular Biology and Pharmacology of Galanin Receptors
Author(s) -
BRANCHEK THERESA,
SMITH KELLI E.,
WALKER MARY W.
Publication year - 1998
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1998.tb10687.x
Subject(s) - galanin , receptor , neuroscience , pharmacology , molecular pharmacology , computational biology , biology , neuropeptide , biochemistry
A bstract : Galanin was first isolated 15 years ago. Diversity of galanin receptors has been suspected from the study of native tissues and functional responses to galanin and galanin‐like peptides in vitro and in vivo . The recent application of molecular biologic techniques to clone galanin receptors has extended this diversity. So far, three galanin receptor subtypes, GALR1, GALR2, and GALR3, have been cloned from both human and rat. Their molecular structure, pharmacologic profiles, tissue distribution, and signal transduction properties have been partially elucidated.