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Analysis of Selected Regulatory Pathways for Rat Galanin Gene Transcription and Their Suitability As Putative Models for Negative Regulation by NGF a
Author(s) -
CORNESS JACQUELINE,
HÖKFELT TOMAS
Publication year - 1998
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1998.tb10680.x
Subject(s) - psychological repression , galanin , transcription factor , biology , microbiology and biotechnology , regulation of gene expression , transcription (linguistics) , ap 1 transcription factor , transcriptional regulation , gene expression , gene , neuropeptide , genetics , receptor , linguistics , philosophy
A bstract : Nerve growth factor (NGF) is known to negatively regulate the transcription of the rat galanin gene both in vivo and in vitro in dorsal root ganglion neurons, yet it is unclear how this regulation actually occurs. We propose here several possible pathways whereby NGF could interact to exert negative control on galanin regulation. These include: (1) repression of AP1‐mediated transcription, (2) repression of nuclear binding protein‐mediated transcription, and (3) repression of cytokine‐mediated transcription. Although not enough data are available for speculation on which, if any, of these pathways is most relevant for NGF repression of galanin transcription, the mechanisms we describe can provide putative models for regulatory pathways. From here we can carry out further experiments that may help to elucidate the possible mechanisms of NGF repression in vivo .