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Effect of Psychotropic Drugs on Taste Responses in Young and Elderly Persons
Author(s) -
SCHIFFMAN SUSAN S.,
GRAHAM BREVICK G.,
SUGGS MARK S.,
SATTELYMILLER ELIZABETH A.
Publication year - 1998
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1998.tb10652.x
Subject(s) - imipramine , taste , doxepin , desipramine , pharmacology , dysgeusia , trifluoperazine , amitriptyline , drug , medicine , chemistry , antidepressant , food science , alternative medicine , pathology , hippocampus , adverse effect , calmodulin , calcium
The taste of six psychotropic drugs (amitriptyline HCl, clomipramine HCl, desipramine HCl, imipramine HCl, doxepin HCl, and trifluoperazine HCl) 'can be detected at concentrations of 0.1 mM or less in both young and elderly individuals. At concentrations 4 times higher than the detection thresholds, these drugs have bitter as well as other unpleasant taste properties. Oral exposure to these drugs not only induces a taste from the drug itself but also alters taste perception of other compounds such as NaCl and sucrose. These results indicate that both hypogeusia and dysgeusia may be induced by psychotropic medications.