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Ionic Mechanism of GABA A Biphasic Synaptic Potentials in Gustatory Nucleus of the Solitary Tract a
Author(s) -
Grabauskas Gintautas,
Bradley Robert M.
Publication year - 1998
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1998.tb10610.x
Subject(s) - inhibitory postsynaptic potential , depolarization , excitatory postsynaptic potential , postsynaptic potential , chemistry , biophysics , nucleus , neuroscience , stimulation , gamma aminobutyric acid , neurotransmission , solitary tract , synaptic cleft , neurotransmitter , biochemistry , biology , receptor
Gamma‐aminobutyric acid (GABA) is the principal neurotransmitter of synaptic inhibition in the gustatory nucleus of the solitary tract (rNST). High‐frequency activation of GABA neurons in the rNST results in biphasic inhibitory postsynaptic potentials (IPSPs) that are initially hyperpolarizing but then became depolarizing. Our results indicate that high‐frequency stimulation evokes redistribution of Cl − and K + ions that shifts IPSP reversal potential in a more positive direction, which produces a biphasic or depolarizing IPSP.