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Organizational Complexity in Lobster Olfactory Receptor Cells a
Author(s) -
ACHE BARRY W.,
MUNGER STEVEN,
ZHAINAZAROV ASLBEK
Publication year - 1998
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1998.tb10565.x
Subject(s) - second messenger system , olfactory receptor , olfactory receptor cell , signal transduction , microbiology and biotechnology , excitatory postsynaptic potential , receptor , biology , olfactory system , neuroscience , intracellular , inositol , chemistry , biochemistry
The current working model of transduction in lobster olfactory receptor cells suggests that: (1) inositol‐1,4,5‐triphosphate (IP 3 ) is the excitatory olfactory second messenger in these cells; (2) activation of the cell also involves a secondary, current‐carrying channel; and (3) the phosphoinositol pathway works in parallel to a second, cyclic nucleotide‐mediated signaling pathway that provides input of opposite polarity into the cell. The complexity of intracellular signaling in lobster olfactory receptor cells renders the cells capable of fine tuning, and even integrating, the signal they send to the brain.