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The Role of Innervation in Induction and Differentiation of Taste Organs: Introduction and Background
Author(s) -
MISTRETTA CHARLOTTE M.
Publication year - 1998
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1998.tb10542.x
Subject(s) - geniculate ganglion , taste , taste bud , neuroscience , sensory system , biology , trigeminal ganglion , ganglion , lingual papilla , neurite , anatomy , taste receptor , denervation , pathology , medicine , biochemistry , alternative medicine , palsy , in vitro
To establish lingual receptive fields that are the basic unit of taste function, ganglion cells must extend neurites to peripheral and central targets and form connections. This symposium concerns developmental interactions between the geniculate, trigeminal and petrosal ganglia and peripheral taste organs, the gustatory papillae and resident taste buds. Investigators present data from organ and tissue culture, from mice with targeted gene deletions and from grafting experiments, in pursuit of principles that direct early innervation of the taste system. The lingual ganglia and the taste papillae initially develop independently, but then become reciprocally dependent as ganglia derive neurotrophin support from gustatory papillae and the papillae require sensory innervation for growth and morphogenesis. The issue of subsequent taste bud induction is discussed with results from amphibian and mammalian models, yielding conclusions that are not yet totally convergent. However, an essential role for sensory innervation in mammalian taste bud differentiation and acquisition of appropriate quantitative relations between ganglion cells and target organs is clearly demonstrated. A working outline is presented for periods of ganglion cell/target organ independence and interdependence during early innervation of the peripheral taste system.