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New Strategy of Thrombolysis: Conjunctive Effect of Plasminogen Activators with Different Pharmacokinetic Profile a
Author(s) -
MAKSIMENKO ALEXANDER V.
Publication year - 1998
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1998.tb10292.x
Subject(s) - thrombolysis , pharmacokinetics , medicine , intravenous bolus , pharmacology , bolus (digestion) , cardiology , myocardial infarction
A bstract : Combined actions of native and prolonged thrombolytics allow the use of lower doses and simplified schemes of administration, thus yielding significant results in experimental therapy regarding the efficacy and safety of thrombolysis. Development of prolonged forms of plasminogen activators and testing their effect in combination with the thrombolysis trigger are well founded and of current interest. Thrombolytic compositions on the basis of short‐ and long‐term‐acting plasminogen activators appear to be promising and potentially eligible for bolus administration.