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New Recognition Elements in Biosensing
Author(s) -
SCHELLER FRIEDER W.,
KLEINJUNG FRANK,
BIER FRANK F.,
MAKOWER ALEXANDER,
NEUMANN BARBARA,
WOLLENBERGER ULLA,
KUROCHKIN ILIYA,
EREMENKO ARKADI,
BARMIN ANATOLI,
KLUβMANN SVEN,
FÜRSTE JENSPETER,
ERDMANN VOLKER A.,
MANSUY D.
Publication year - 1998
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1998.tb10286.x
Subject(s) - molecular recognition , aptamer , biosensor , biomolecule , oligonucleotide , chemistry , combinatorial chemistry , biochemistry , molecule , microbiology and biotechnology , biology , organic chemistry , dna
A bstract : The borderline between molecular recognition element (MRE) tools that are biological in nature and synthetic (organic) receptor molecules is no longer well definable; these two classes of recognition elements are merging. This is especially true for enzyme models, polymers imprinted by biomolecules, ionophores (which mimic the function of channels), and (synthetic) oligonucleotides. In this paper, we introduce three new examples of modified recognition elements for biosensing: (i) bienzyme conjugates for quantification of inhibitors of choline esterase; (ii) recognition of l‐adenosine by high‐affinity oligonucleotides (aptamers); (iii) catalyzed conversion of alkanes by hydroperoxides in the presence of porphyrin complexes.