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Interactions between Effectors Linked to Serotonin Receptors
Author(s) -
BERG K. A.,
MAAYANI S.,
CLARKE W. P.
Publication year - 1998
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1998.tb10181.x
Subject(s) - serotonin , receptor , effector , 5 ht receptor , neuroscience , chemistry , microbiology and biotechnology , biology , biochemistry
In general, there are two types of interactions between effector signaling pathways. “Homologous” interactions are those that occur within a receptor system to alter its own responsiveness, for example the loss of responsiveness (desensitization) that can occur upon agonist occupancy of a receptor. “Heterologous” interactions are those that occur between different receptor systems where the responsiveness of one receptor system is regulated (positively or negatively) by activation of another receptor system ( i.e. , “cross‐talk”). Many, if not all receptors, couple to multiple cellular effector pathways and alterations in the responsiveness of a receptor system can be effector pathway‐dependent which underscores the importance of studying each effector coupled to a receptor. Regulation of receptor system responsiveness, and consequently the efficacy of drugs, is a highly dynamic process. Perhaps by exploiting these interactions, new targets for pharmacotherapy may be uncovered which will provide for increased efficacy and specificity of drug action.