Premium
The Putative 5‐ht 6 Receptor: Localization and Function
Author(s) -
SLEIGHT A. J.,
BOESS F. G.,
BÖS M.,
BOURSON A.
Publication year - 1998
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1998.tb10178.x
Subject(s) - receptor , 5 ht receptor , biology , cloning (programming) , function (biology) , gene , neurotransmitter receptor , neuroscience , neurotransmitter , serotonin , computational biology , microbiology and biotechnology , genetics , computer science , programming language
Until recently, the majority of actions of the neurotransmitter 5‐hydroxytryptamine (5‐HT) were generally believed to be mediated by members of the 5‐HT 1 , 5‐HT 2 , 5‐HT 3 and 5‐HT 4 receptor families. The application of molecular cloning techniques has revealed the existence of gene products encoding several novel, putative 5‐HT receptors for which little or no prior pharmacological or functional data presently exist. The present challenge to pharmacologists is to determine the physiological relevance of these gene products, establish whether or not they function as endogenous receptors, find selective agents and determine potential therapeutic uses of these compounds. Here we review work detailing the cloning and characterization of the recombinant 5‐ht 6 receptor, its distribution and evidence for functional responses mediated by naturally occurring 5‐ht 6 receptors.