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5‐HT 1B Receptor Modulation of Prepulse Inhibition: Recent Findings in Wild‐type and 5‐HT 1B Knockout Mice a
Author(s) -
DULAWA S. C.,
HEN R.,
SCEARCELEVIE K.,
GEYER M. A.
Publication year - 1998
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1998.tb10176.x
Subject(s) - prepulse inhibition , knockout mouse , moro reflex , agonist , 5 ht receptor , serotonin , receptor , neuroscience , reflex , chemistry , psychology , sensory gating , gating , pharmacology , endocrinology , medicine , schizophrenia (object oriented programming) , psychiatry , biochemistry
Sensorimotor gating of the startle reflex occurs when the presentation of a weak “prepulse” 30–500 msec prior to a startling stimulus inhibits the reflex, and is called prepulse inhibition (PPI). The study of PPI has recently been extended to mice to take advantage of recent advances in molecular genetics, because several neuropsychiatric disorders including schizophrenia, obsessive compulsive disorder, and schizotypal personality disorder are characterized by PPI deficits 1,2,3. Studies in wild‐type and 5‐HT 1B knockout mice suggest that activation of 5‐HT 1B receptors decreases PPI. The direct 5‐HT 1A/1B agonist RU24969 decreases PPI in wild‐type but not 5‐HT 1B knockout mice. Likewise, the serotonin releasing compounds MDMA(+), MBDB(±), and alpha‐ethyltryptamine (AET) have no effect on PPI in wild‐type mice, but increase PPI in 5‐HT 1B knockout mice. As the direct 5‐HT 1A agonist 8‐OH‐DPAT increases PPI in mice, the unmasking of these effects may also contribute to the PPI‐increasing effects of 5‐HT releasers in 5‐HT 1B knockout mice.