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Serotonin Receptor Variants in Disease: New Therapeutic Opportunities?
Author(s) -
PEROUTKA S. J.
Publication year - 1998
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1998.tb10168.x
Subject(s) - schizophrenia (object oriented programming) , disease , receptor , gene , genetic association , function (biology) , genetics , depression (economics) , biology , computational biology , bioinformatics , neuroscience , medicine , psychiatry , genotype , single nucleotide polymorphism , macroeconomics , economics
This review describes a novel genetic approach to the assessment of receptor function that is based on association studies of polymorphisms within human genes. The realization that variations within human genes may significantly affect gene function has led to increased use of this approach in recent years. Analysis of polymorphisms within the human 5‐HT 2A receptor is used as a specific example of the application of association genetics to elucidate gene function. The interaction of many neuroleptics and antidepressants with 5‐HT 2A receptors points up the potential importance of this receptor for understanding and treating neuropsychiatric disorders such as schizophrenia and depression.