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5‐HT 4 Receptors: Gene, Transduction and Effects on Olfactory Memory
Author(s) -
BOCKAERT J.,
CLAEYSEN S.,
SEBBEN M.,
DUMUIS A.
Publication year - 1998
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1998.tb10167.x
Subject(s) - receptor , 5 ht receptor , context (archaeology) , chemistry , microbiology and biotechnology , 5 ht1 receptor , biology , g protein coupled receptor , serotonin , neuroscience , pharmacology , biochemistry , paleontology
In this paper we discuss 1) the primary structures, pharmacology, and brain distribution of cloned 5‐HT 4 receptors; 2) the chromosomal localization of the h5‐HT 4 receptor; 3) whether benzamides are full or partial agonists because of a species or a coupling difference; 4) the intrinsic activity of 5‐HT 4 receptors and inverse agonism of GR125487 in COS‐7 cells but not in colliculi neurons; 5) the modulation of 5‐HT 4 receptor binding and activity; and 6) the long‐term blockade of K + channels by 5‐HT 4 agonists and its effect on olfactory memory. We conclude that 1) the cloning of 5‐HT 4 receptors in different species using RT‐PCR from different tissues reveals the presence of several splice variants for 5‐HT 4 receptors differing in the C‐terminal part, downstream from the amino acid L 358 ; 2) the pharmacological properties of 5‐HT 4 receptors are dependent on the cellular context in which they are expressed; and 3) 5‐HT 4 agonists can be added to the list of compounds having pro‐cognitive properties.