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Non‐Linear Microscale Alterations in Membrane Transport by Electropermeabilization a
Author(s) -
GOWRISHANKAR T. R.,
CHEN WEI,
LEE RAPHAEL C.
Publication year - 1998
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1998.tb10154.x
Subject(s) - electroporation , microscale chemistry , biophysics , membrane potential , membrane , voltage clamp , clamp , chemistry , conductance , patch clamp , transmembrane protein , electrophysiology , biology , physics , neuroscience , biochemistry , computer science , mathematics , mathematics education , clamping , condensed matter physics , computer vision , gene , receptor
The purpose of this study was to quantify the changes in cell membrane conductance in response to electropermeabilization, which may elucidate the mechanisms of tissue injury resulting from high‐voltage electrical shock. A high‐speed, space‐clamp and voltage‐clamp experimental configuration was used. The pulse parameters of an imposed transmembrane potential that are instrumental in membrane properties alteration were precisely controlled. The dynamics of the non‐linear electroporation response was characterized.