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Coupling of the p75 Neurotrophin Receptor to Sphingolipid Signaling a
Author(s) -
DOBROWSKY RICK T.,
CARTER BRUCE D.
Publication year - 1998
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1998.tb09660.x
Subject(s) - low affinity nerve growth factor receptor , ceramide , neurotrophin , trk receptor , microbiology and biotechnology , tropomyosin receptor kinase c , nerve growth factor , tropomyosin receptor kinase a , lipid signaling , biology , neurotrophin 3 , receptor , signal transduction , receptor tyrosine kinase , chemistry , platelet derived growth factor receptor , neurotrophic factors , brain derived neurotrophic factor , biochemistry , growth factor , apoptosis
The neurotrophins are a family of growth factors involved in the survival and differentiation of specific populations of neurons and glial cells. Many of the trophic signals elicited by neurotrophins are initiated by the binding of these molecules to various Trk tyrosine kinase receptors. In contrast, recent data suggest that neurotrophin‐mediated death signals are generated through the interaction of nerve growth factor with the low‐affinity neurotrophin receptor, p75 NTR . Neurotrophins may signal through p75 NTR by stimulating sphingomyelin hydrolysis and generating ceramide in primary cultures of neurons and glial cells as well as in fibroblasts heterologously expressing p75 NTR . The biochemical characteristics of p75 NTR ‐dependent ceramide generation are discussed relative to the role of ceramide in p75 NTR ‐dependent apoptosis and the activation of NF‐κB.