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Confocal Imaging of Gene Expression during Hamster Submandibular Gland Biogenesis
Author(s) -
FERNANDES RUI,
FOX MATTHEW,
COTANCHE DOUGLAS,
LEN KELLEY,
KUKURUZINSKA MARIA A.
Publication year - 1998
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1998.tb09652.x
Subject(s) - hamster , microbiology and biotechnology , gene expression , submandibular gland , biology , salivary gland , cellular differentiation , downregulation and upregulation , biogenesis , regulation of gene expression , gene , genetics , endocrinology , biochemistry
The data presented here provide evidence that the abundance of the ALG7 protein product, GPT, correlates with high proliferative activity during the postnatal development of the hamster SMG development, and that it becomes downregulated with differentiation. Based on our previous studies with yeast, changes in the level of ALG7 expression may be necessary for the events directing salivary cell polarization, migration, differentiation, and apoptosis at distinct developmental stages.