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Apoptosis: A Modulator of Cellular Homeostasis and Disease States
Author(s) -
DELONG MARY J.
Publication year - 1998
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1998.tb09635.x
Subject(s) - apoptosis , homeostasis , endogeny , microbiology and biotechnology , disease , detoxification (alternative medicine) , biology , immunology , medicine , endocrinology , biochemistry , pathology , alternative medicine
A bstract : In normal epithelial tissue, a homeostatic balance is maintained between cell replication and apoptosis. Disruption of this balance has serious pathological consequences in disease states, such as Sjögren's syndrome, salivary gland degeneration, and cancers. Apoptosis may be modulated by cytokine endogenous factors and exogenous factors. A vast array of environmental compounds, such as differentiating agents and microconstituents found in the diet, initiate apoptosis through a redox signal mechanism. In addition to increasing apoptosis, these redox signals and transient or permanent changes in cellular redox status elevate detoxification enzymes known to protect against many disease states. Clearly a further understanding of the regulation of apoptosis and protective enzyme elevation by exogenous redox signals will lead to the development of future therapeutic strategies against disease.