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The Role of the Insulin‐like Growth Factor I Receptor in Transformation and Apoptosis
Author(s) -
RESNICOFF MARIANA,
BASERGA RENATO
Publication year - 1998
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1998.tb09634.x
Subject(s) - apoptosis , insulin like growth factor , growth factor , in vivo , microbiology and biotechnology , receptor , cell growth , insulin like growth factor receptor , transformation (genetics) , in vitro , phenotype , chemistry , insulin , insulin receptor , growth factor receptor , cancer research , medicine , endocrinology , biology , signal transduction , insulin resistance , biochemistry , gene , genetics
A bstract : The insulin‐like growth factor I receptor (IGF‐IR) regulates cell proliferation by at least three different mechanisms: (1) it is mitogenic; (2) it is required for the establishment and maintenance of the transformed phenotype; and (3) it protects cells from apoptosis both in vitro and in vivo .