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Insulin Growth Factor‐I Inhibits Apoptosis in Hematopoietic: Progenitor Cells Implications in Thymic Aging a
Author(s) -
KELLEY KEITH W.,
MEIER WILLIAM A.,
MINSHALL CHRISTIAN,
SCHACHER DANIEL H.,
LIU QIANG,
VANHOY ROGER,
BURGESS WILLIAM,
DANTZER ROBERT
Publication year - 1998
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1998.tb09590.x
Subject(s) - haematopoiesis , biology , progenitor cell , microbiology and biotechnology , growth factor , apoptosis , myeloid , insulin like growth factor , involution (esoterism) , signal transduction , intracellular , stem cell , endocrinology , medicine , cancer research , receptor , biochemistry , neuroscience , consciousness
A bstract : A decline in plasma concentrations of both growth hormone and IGF‐I occurs during aging of humans and rodents, and this is accompanied by involution of the thymus gland. Exogenous growth hormone induces the synthesis of IGF‐I, which acts on bone marrow‐derived hematopoietic progenitors of the myeloid and lymphoid lineages to promote their replication and survival. The increase in survival of these cells is caused by the ability of IGF‐I to inhibit their apopotic death. In contrast to the multipotential colony‐stimulating‐factor IL‐3, inhibition of apoptosis by IGF‐I requires the activation of the critical intracellular effector PI 3‐kinase. These data establish that hematopoietic progenitors can use more than one intracellular signaling pathway in order to maintain their survival. The data also extend the original hypothesis 48 that IGF‐I shares with the colony‐stimulating factors the properties of promoting DNA synthesis and inhibiting programmed cell death. Collectively, these data establish that hematopoietic progenitor cells are important targets for IGF‐I, and this is likely to be important in understanding thymic aging.