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Contribution of the ICE Family to Neurodegeneration
Author(s) -
SHIVERS BRENDA D.,
BOXER PETER A.,
KEANE KAREN M.,
KUPINCY C.,
LYNCH TONI,
SCHIELKE GERALD P.,
VARTANIAN MARK G.,
VASILAKOS JOHN P.
Publication year - 1998
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1998.tb09549.x
Subject(s) - neurodegeneration , proteases , disease , neuroscience , intracellular , apoptosis , nervous system , biology , microbiology and biotechnology , medicine , pathology , genetics , biochemistry , enzyme
A bstract : The ICE family of cysteine proteases mediates necrotic or apoptotic events in the nervous system as well as in other tissues. This suggests that inhibitors may be of therapeutic value in acute and, perhaps, chronic neurode‐generative disease. In addition, some members of this family may respond to intercellular signals controling proliferation or differentiation. This possibility should be kept in mind as therapeutics are pursued.