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Mitogen‐Activated Protein Kinase Cascades as Regulators of Stress Responses
Author(s) -
KARIN MICHAEL
Publication year - 1998
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1998.tb08987.x
Subject(s) - mapk cascade , mapk/erk pathway , microbiology and biotechnology , protein kinase a , mitogen activated protein kinase , kinase , transcription factor , signal transduction , osmotic shock , chemistry , phosphorylation , biology , biochemistry , gene
Mitogen-activated protein kinase (MAPK) cascades play an important role in transducting environmental stimuli to the transcriptional machinery in the nucleus by virtue of their ability to phosphorylate and regulate the activity of various transcription factors. Originally found to be activated in response to occupancy of cell surface receptors for polypeptide hormones, cytokines, and growth factors, MAPK cascades were recently found to be activated by a variety of stresses including ischemia reperfusion, neuronal injury, osmotic shock, and exposure to UV irradiation. Therefore, MAPK cascades are likely to be important regulatory elements in a variety of stress responses.