Premium
Immunohistochemical Changes of the Transcription Regulatory Factors in Rat Striatum after Methamphetamine Administration
Author(s) -
MURATAKE TATSUYUKI,
TOYOOKA KAZUHIKO,
HAYASHI SHIGENOBU,
ICHIKAWA TOMIO,
KUMANISHI TOSHIRO,
TAKAHASHI YASUO
Publication year - 1998
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1998.tb08218.x
Subject(s) - creb , striatum , methamphetamine , cyclic adenosine monophosphate , cyclic amp response element binding protein , response element , gene expression , adenosine , biology , endocrinology , microbiology and biotechnology , medicine , transcription factor , gene , pharmacology , biochemistry , promoter , receptor , dopamine
We have found evidence for cyclic adenosine monophosphate (cAMP) response element (CRE) in the 5′‐upstream region of the human 14.3.3 η chain gene during studies on isolation and structure of animal brain 14.3.3 cDNA and the human 14.3.3 h chain gene. cAMP response element‐binding protein (CREB) and phosphorylated CREB (pCREB) may bind to this CRE. Since it was considered that these CREBs may play an important role in molecular mechanisms in the brain of animals treated with methamphetamine, we examined the expression of CREB and pCREB in rat brain after acute and chronic methamphetamine administrations using antibodies against CREB and pCREB. We observed findings for change in the expression of these factors. Our findings should be discussed in relation to the data of other authors.