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Spectral Pathology a
Author(s) -
ZONIOS GEORGE,
COTHREN ROBERT,
CRAWFORD JAMES M.,
FITZMAURICE MARYANN,
MANOHARAN RAMASAMY,
DAM JACQUES,
FELD MICHAEL S.
Publication year - 1998
Publication title -
annals of the new york academy of sciences
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1998.tb08191.x
Subject(s) - pathology , raman spectroscopy , fluorescence , dysplasia , fluorescence spectroscopy , spectroscopy , optics , medicine , physics , quantum mechanics
We are investigating the use of optical spectroscopy (fluorescence, reflectance, Raman scattering) for detecting precancerous lesions in the mucosal linings of hollow organs. We present a morphological model for extracting quantitative pathological information from fluorescence spectra, using colonic dysplasia as an example. The potential of this technique in providing histological information in real time without the need for tissue removal is discussed.