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Results of a Long‐term Experimental Study on the Carcinogenicity of Vinyl Acetate Monomer in Mice
Author(s) -
MALTONI CESARE,
CLIBERTI ADRIANO,
LEFEMINE GIUSEPPE,
SOFFRITTI MORANDO
Publication year - 1997
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1997.tb56876.x
Subject(s) - offspring , carcinogen , stomach , esophagus , lung , embryo , vinyl acetate , tongue , physiology , medicine , biology , endocrinology , chemistry , pregnancy , pathology , biochemistry , genetics , organic chemistry , copolymer , microbiology and biotechnology , polymer
Vinyl acetate monomer (VAM) was administered in drinking water at doses of 5,000, 1,000, and 0 ppm (v/v), to Swiss mice, 17 weeks old (breeders) or 12-day embryos (offspring) at the start of the experiment. The treatment lasted 78 weeks, and the animals were kept under control until spontaneous death. VAM has been shown to cause an increase in: (1) total malignant tumors; (2) carcinomas of the Zymbal glands, oral cavity, tongue, esophagus, and forestomach; (3) stomach tumors; (4) lung tumors; and (5) uterine tumors. A slight increase of hepatomas has been observed among male mice offspring treated with the higher dose. On the basis of these data VAM must be considered a multipotential carcinogen.