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Immunoisolation of Adult Porcine Islets for the Treatment of Diabetes Mellitus
Author(s) -
HILL RONALD S.,
CRUISE GREG M.,
HAGER STEVE R.,
LAMBERTI FRANCIS V.,
YU XIAOJIE,
GARUFIS CARRIE L.,
YU YAO,
MUNDWILER KAREN E.,
COLE JOHN F.,
HUBBELL JEFFERY A.,
HEGRE ORION D.,
SCHARP DAVID W.
Publication year - 1997
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1997.tb52208.x
Subject(s) - islet , diabetes mellitus , insulin , medicine , endocrinology , function (biology) , microbiology and biotechnology , chemistry , biology
Functional porcine islets, free of known pathogens, can serve as a source of insulin producing cells for the treatment of experimentally induced insulin dependent Diabetes Mellitus. Porcine islets can be conformally coated (microencapsulated) with a covalently linked, stable permselective membrane while maintaining islet viability and function. The PEG conformal coating is immunoprotective in a discordant xenograft animal model (porcine islets to rat).