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Anionic Polymers for Implantation
Author(s) -
SMETANA KAREL,
VACÍK JIŘÍ
Publication year - 1997
Publication title -
annals of the new york academy of sciences
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1997.tb52187.x
Subject(s) - karel , czech , slovak , citation , classics , library science , chemistry , philosophy , art , art history , computer science , linguistics
The biocompatibility of hydrogels containing carboxylate anions was studied by a panel of tests in vitro and in vivo. In comparison with other types of similar hydrogels, those with COO- anions induced a lower extent of foreign body reaction, and their systemic effect on the immune system also seems lower. The biomimetic effect of carboxylate anions on biocompatibility of synthetic materials could be explained by a similar biomimetic effect of N-acetylneuraminic acid inhibiting the non-self recognition of bacterial cells by non-specific immunity. The encouraging long-term results of clinical trials of intraocular lenses prepared from copolymer of 2-hydroxyethyl methacrylate and sodium methacrylate support this hypothesis.