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Bone Mineral Metabolism in Diet‐Induced Amenorrhea
Author(s) -
BRUNI VINCENZINA,
BIGOZZI LUISA,
DEI METELLA,
BRANDI M. LUISA
Publication year - 1997
Publication title -
annals of the new york academy of sciences
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1997.tb52149.x
Subject(s) - amenorrhea , metabolism , endocrinology , bone mineral , bone remodeling , medicine , physiology , chemistry , osteoporosis , biology , pregnancy , genetics
Spinal bone density of 41 girls with diet-induced amenorrhea (DA) was compared with that of the density of 22 subjects with premature ovarian failure (POF) of comparable age. The Z score values, as well as the estradiol levels, were not significantly different in the two groups. The duration of amenorrhea was significantly correlated to bone mass density in the DA population, especially when considering subjects with amenorrhea that had lasted longer than 20 months. A similar correlation between weight loss and BMD was evident. Although estradiol concentrations did not seem to be correlated to the Z score, FT3 and cortisol values exhibited, respectively, a negative and a positive correlation with spinal density. Cortisol seemed to act precociously, whereas FT3 acted later than cortisol.