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Hormonal Regulation of N‐Cadherin mRNA Levels in Rat Granulosa Cells a
Author(s) -
FAROOKHI RIAZ,
GENG CHANGSHAN,
MacCALMAN COLIN D.,
BLASCHUK OREST W.
Publication year - 1997
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1997.tb52140.x
Subject(s) - obstetrics and gynaecology , annals , medicine , physiology , library science , gynecology , biology , history , pregnancy , classics , genetics , computer science
We have examined the ability of hormones to modulate the steady-state levels of N-cadherin mRNA transcripts in aggregated and dispersed rat granulosa cell populations. Estradiol and follicle-stimulating hormone (FSH) had no effect on the levels of N-cadherin mRNA transcripts in aggregated granulosa cells. In contrast, these two hormones stimulated N-cadherin mRNA levels in dispersed granulosa cells. This is the first report that estradiol and FSH are capable of regulating N-cadherin mRNA levels. The results also suggest that the N-cadherin mRNA levels in dispersed and aggregated granulosa cells are regulated by different mechanisms.