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CDRH3 Length Is the Target of Selection of Disease‐associated IgM Autoantibodies a
Author(s) -
LIPSANEN V.,
WALTER B.,
EMARA M.,
SIMINOVITCH K.,
LAM J.,
KAUSHIK A.
Publication year - 1997
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1997.tb52099.x
Subject(s) - christian ministry , library science , medicine , gerontology , geography , demography , family medicine , political science , sociology , computer science , law
The experiments outlined here provide evidence for positive selection of B-1 lymphocytes secreting IgM autoantibodies in the autoimmune mev mice as a result of the reduced threshold of responsiveness to autoantigens because of PTP1C deficiency, which is targeted at the CDR3 length of the variable region of the heavy chain. In addition, characteristic differences in the size, hydrophobicity pattern, and relative local charge of the CDR3 of the heavy chain of disease-associated IgM autoantibodies from moth-eaten mice help distinguish them from physiological natural autoantibodies present in normal mice.