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Analysis of CD40‐CD40 Ligand Interactions in the Regulation of Human B Cell Function a
Author(s) -
LIPSKY PETER E.,
ATTREP JEANNE F.,
GRAMMER AMRIE C.,
McILRAITH MELISSA J.,
NISHIOKA YUICHI
Publication year - 1997
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1997.tb52088.x
Subject(s) - cd40 , germinal center , microbiology and biotechnology , b cell , function (biology) , ligand (biochemistry) , chemistry , biology , antibody , immunology , receptor , in vitro , biochemistry , cytotoxic t cell
CD40-CD40 ligand interactions play an essential role in T cell/B cell collaboration. The data presented in this review have served to widen the scope of CD40-CD40 ligand interactions to include initial activation, proliferation, differentiation, and isotype switching of B cells, as well as subsequent downregulation of B cell function. Moreover, CD40 ligand expression by activated B cells is likely to play an essential role in facilitating ongoing responses of stimulated B cells maturing in germinal centers. Finally, CD40 expression by activated T cells may also play an important role in regulating the function of helper T cells within germinal centers. In summary, emerging data have expanded the role of CD40-CD40 ligand interaction during T cell/B cell collaboration and have emphasized its potential to regulate many of the functions of both partners in this essential interaction involved in antibody production.