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Diet‐induced Insulin Resistance Is Associated with Decreased Activity of Type I Iodothyronine 5′‐Deiodinase in Rat Liver a
Author(s) -
BRANSOVÁ J.,
BRTKOVÁ A.,
šEBÖKOVÁ E.,
KLIMEš I.,
LANGER P.,
BRTKO J.
Publication year - 1997
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1997.tb51858.x
Subject(s) - medicine , endocrinology , iodothyronine deiodinase , selenium , insulin resistance , chemistry , deiodinase , sucrose , insulin , basal (medicine) , thyroid , thyroid hormones , biology , biochemistry , organic chemistry
The effect of feeding Wistar rats with high-sucrose (63 wt% of sucrose, HS) or high-fat (30 wt% of fat, HF) diets for two weeks on serum selenium concentration and type I iodothyronine 5'-deiodinase (5'-DI) activity in liver was investigated. No significant differences in serum selenium concentration (as determined by graphite-furnace atomic absorption spectrometry) were found among the groups of rats fed basal, HS, or HF diets. A significant reduction of the 5'-DI activity (p < 0.005-0.05) was found in groups of rats fed either HS or HF diet in comparison with rats fed B diet. In conclusion, it is suggested that decreased 5'-DI activity in HS or HF diet-induced insulin resistance is not due to selenium status, but it may involve other dietary-related factors.