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Analysis of the Cellular Mechanism for Halothane Inhibition of Brown Adipose Tissue Thermogenesis
Author(s) -
OHLSON KERSTIN B. E.,
LINDAHL STEN G. E.,
CAN BARBARA,
NEDERGAARD JAN
Publication year - 1997
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1997.tb51773.x
Subject(s) - anesthesiology , university hospital , medicine , intensive care , emergency medicine , anesthesia , intensive care medicine
In the present studies, halothane is demonstrated to have a general inhibitory effect on norepinephrine-induced cAMP accumulation, lipolysis and rate of oxygen consumption, but no obvious effect on the respiratory capacity of isolated mitochondria. Further studies are necessary to elucidate these effects of halothane on brown adipose tissue nonshivering thermogenesis. Such studies may contribute to the understanding of the molecular effects of volatile anesthetics.