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Possible Role of Cyclooxygenase‐2 in the Brain Vasculature in Febrile Response
Author(s) -
MATSUMURA KIYOSHI,
CAO CHUNYU,
WATANABE YASUYOSHI
Publication year - 1997
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1997.tb51709.x
Subject(s) - library science , corporation , medicine , political science , computer science , law
These results support the hypothesis that the brain vasculature is the site of PGE2 production responsible for LPS-induced fever. LPS seems to increase the PGE2 level in the entire brain via the induction of COX-2. Fever may be mediated by PGE2 which is produced in the blood vessels in the preoptic area or which is produced in other parts of the brain and transported to the preoptic area through the ventricular system.