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Multifaceted Roles for IGFBP‐1 in Human Endometrium during Implantation and Pregnancy
Author(s) -
GIUDICE LINDA C.
Publication year - 1997
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1997.tb48533.x
Subject(s) - reproductive endocrinology and infertility , obstetrics and gynaecology , citation , infertility , annals , gynecology , endometrium , reproductive endocrinology , medicine , library science , obstetrics , pregnancy , computer science , history , biology , classics , hormone , genetics
IGFBP-1 is a major protein product of nonpregnant endometrium during the mid-late secretory phase and occurs in abundance in decidua. Its roles as an IGF-binding protein and as a trophoblast integrin ligand suggest that it may have multiple roles in endometrial development and in interactions between the decidua and the invading trophoblast. IGFBP-1 in vaginal/cervical secretions has already had clinical application as a predictor of premature rupture of fetal membranes. The future awaits elucidation of the potential utility of IGFBP-1 in serum and in decidua in predicting fetal growth restriction and preeclampsia and perhaps implantation failure.