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Importance of Vascular Changes in Selective Neurodegeneration with Thiamine Deficiency
Author(s) -
GIBSON G. E.,
CALINGASAN N. Y.,
BAKER H.,
GANDY S.,
SHEU K.F. R.
Publication year - 1997
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1997.tb48517.x
Subject(s) - white (mutation) , medical school , medical science , library science , gerontology , medicine , medical education , chemistry , computer science , gene , biochemistry
These results demonstrate that early alterations in the BBB may underlie selective vulnerability in this model of chronic reduced oxidative metabolism. Changes in the BBB (IgG extravasation) precede alterations in APP processing and cell death. Since thiamine-dependent enzymes are also reduced in the brain in Alzheimer's disease, similar processes may be important in the pathophysiology of the disease.