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Inherent Abnormalities in Oxidative Metabolism in Alzheimer's Disease: Interaction with Vascular Abnormalities
Author(s) -
BLASS JOHN P.,
SHEU KWANFU R.,
PIACENTINI SILVIA,
SORBI SANDRO
Publication year - 1997
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1997.tb48488.x
Subject(s) - oxidative metabolism , disease , metabolism , oxidative phosphorylation , pathophysiology , alzheimer's disease , energy metabolism , carbohydrate metabolism , oxygen metabolism , medicine , oxidative damage , cellular metabolism , neuroscience , oxidative stress , oxygen , biology , chemistry , biochemistry , organic chemistry
Extensive studies over the last 20 years have documented the existence of inherent abnormalities in oxidative/energy metabolism in Alzheimer's disease (AD). These abnormalities can be linked to characteristics of AD by plausible pathophysiological mechanisms for which there is abundant, robust evidence. The inherent abnormalities in cerebral metabolism of oxygen and glucose can reasonably be expected to interact synergistically with vascular compromise of cerebral oxygen and glucose metabolism in causing brain damage in AD.