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Decreased Brain Glucose Metabolism in Microvessels from Patients with Alzheimer's Disease a
Author(s) -
MARCUS DAVID L.,
FREEDMAN MICHAEL L.
Publication year - 1997
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1997.tb48476.x
Subject(s) - hexokinase , alzheimer's disease , carbohydrate metabolism , metabolism , endocrinology , medicine , in vivo , phosphorylation , glucose uptake , chemistry , disease , biology , biochemistry , glycolysis , microbiology and biotechnology , insulin
We studied brain glucose metabolism in patients with Alzheimer's disease and age‐matched controls in vivo by PET and assessed brain glucose utilization and the phosphorylation constant K 3 for hexokinase. In addition we determined in vitro the binding of 2DG and measured its phosphorylation to 2DG‐phosphate in cerebral microvessels obtained at autopsy from subjects with Alzheimer's disease and age‐matched controls. In patients with Alzheimer's disease we found a marked decrease in the kinetic constant K 3 for the hexokinase, and a marked decrease in the overall metabolism of glucose in our PET studies; in microvessels there was a marked decrease in the affinity of 2DG and a decrease in hexokinase activity. Alzheimer's disease may be related to a complex alteration in brain glucose metabolism.