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Neuroimaging of Vessel Amyloid in Alzheimer's Disease a, b
Author(s) -
FRIEDLAND ROBERT P.,
KALARIA RAJESH,
BERRIDGE MARC,
MIRALDI FLORO,
HEDERA PETER,
RENO JOHN,
LYLE LEON,
MAROTTA CHARLES A.
Publication year - 1997
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1997.tb48475.x
Subject(s) - scalp , amyloid (mycology) , antibody , pathology , medicine , beta (programming language) , monoclonal antibody , technetium , positron emission tomography , alzheimer's disease , amyloid beta , nuclear medicine , chemistry , disease , immunology , anatomy , computer science , programming language
Despite extensive recent advances in understanding Alzheimer's disease (AD) we are unable to noninvasively establish a definite diagnosis during life and cannot monitor the cerebral deposition of amyloid β protein (A/β) in living patients. We evaluated the use of 10H3, a monoclonal antibody Fab targeting Aβ protein 1‐28 labeled with Tc‐99m. Six subjects with probable AD were studied using single‐photon emission computed tomography (SPECT) at times from 0–24 hours following injection. Curves of radioactivity in blood demonstrate a half‐life of the injected Fab of 2–3 hours. Images show uptake around the head in the scalp or bone marrow in all subjects. There is no evidence of cerebral uptake of the antibody. Scalp biopsies in all six patients demonstrate diffuse staining with 10H3 of the scalp, a pattern indistinguishable from that found in controls. Evidence of amyloid deposition in the scalp in AD is not seen with other anti‐Aβ antibodies, suggesting that 10H3 is cross‐reacting with another protein. Further studies with anti‐Aβ antibodies will require longer‐lived radionuclides to detect cerebral uptake at later tunes after injection to allow for complete clearance from the blood. Afternately, imaging using labeled Aβ itself may provide a means for noninvasive targeting of cerebral amyloid.